Gestrinone is a weak synthetic progesterone originally developed in the 1970s for use as a once-a-week contraceptive. First used as a treatment for endometriosis in the early 1980s, it has since been used in clinical trials in several European countries. It is not currently available in Australia.
How Gestrinone works
Gestrinone appears to work by suppressing the secretion of oestrogen by the ovaries, causing the endometrial implants to degenerate and waste away.
Dosages of Gestrinone generally used
At the moment clinical trials are still trying to identify the most effective dosage. It appears that dosages of 2.5 to 5.0 milligrams two or three times a week are likely to be effective.
Side effects of Gestrinone
The side effects are reported to be moderate and similar to those of Danazol, and include acne, increased appetite, vaginal discharge, irregular vaginal bleeding, headaches, decreased breast size, nausea, weight gain, excessive hair growth and depression.
How effective is Gestrinone
Early clinical trials have indicated that Gestrinone is an effective treatment for endometriosis and that overall it is as effective as Danazol. Its future role in the treatment of endometriosis is not known at this stage.
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